Associate Professor of Chemical and Biological Engineering, McCormick School of Engineering and Applied Science; Co-Director of the Recombinant Protein Production Core
The Tyo Lab is focused on developing new types of standardized parts for manipulating cellular function in microbes. By exploiting post-translational biological processes, they hope to improve biochemical production of fuels, chemicals, and whole-cell biosensors.
Microbes must cope with harsh, rapidly changing environments to survive. To do this, microbes have developed sophisticated mechanisms to (a) sense the changes in the environment, and (b) respond quickly to these changes to protect itself from harm or capitalize on an opportunity. The Tyo lab seeks to rewire these fundamental input/output relationships to program cells to do useful things for mankind in a paradigm called synthetic biology. Inputs: They study methods to modify existing environmental detection sensors in yeast and modify them to detect new analytes. Outputs: They investigate ways microbes modify their metabolic networks and use these modifications to increase production of a given metabolite.
Dr. Tyo received his B.S. from West Virginia University and M.S. and PhD from the Massachusetts Institute of Technology (MIT). He has been named the NIH Kirschstein NRSA Fellow, Chalmers University of Technology and received the Searle Leadership Award.
Office: Tech E156
Email: k-tyo [at] northwestern [dot] edu