The Howard Taylor Ricketts Professor of Medicine-Infectious Diseases, Feinberg School of Medicine; Director of Northwestern HIV Translational Research Center
The D’Aquila laboratory studies the APOBEC3 (A3) family of human cytidine deaminases. These “HIV restriction factors” are antagonized by HIV Vif and were selected over the course of evolution for activity against endogenous retroelements. The laboratory pioneered evidence that high physiological levels of A3G and A3F are active in producer and target cells against wild-type (Vif-positive) HIV-1 in vitro, and that such higher levels contribute to the spontaneous control of HIV-1 in vivo. The laboratory was also the first to discover that some A3s (such as A3F) are highly localized within the mature HIV virion core during assembly, while others (such as A3G) are distributed both within and outside the core. The goal of research is to boost A3 defenses against HIV to prevent or minimize its persistence.
Office: 303 East Superior Street, 9-159
Email: richard [dot] daquila [at] northwestern [dot] edu
Ginne K. Meyers
Office: 303 East Superior Street, 9th floor
Email: g-meyers [at] northwestern [dot] edu