Proteomics Center of Excellence (PCE)

PCE.jpgDirector: Neil Kelleher, Ph.D.
Associate Director: Paul Thomas, Ph.D.

Location: Silverman Hall B550


The Proteomics Center of Excellence (PCE) is focused on the qualitative and quantitative detection of as many cellular components as possible at the protein level. The center will implement known technologies for “Bottom Up”, but emphasize the philosophy of ‘precision proteomics,’ which uses high performance mass spectrometry to deliver protein identifications with very high confidence and in a gene-specific fashion.  Quantitation of protein expression and confident assignment of post-translational modifications will also be possible in a highly collaborative framework.

The Center will also develop next-generation proteomics using intact proteins (i.e., the “Top Down” approach) and efficiently translate this frontier approach to Northwestern Investigators on the main campus and at the Feinberg School of Medicine.  The PCE will bridge the usual performance gap between top proteomics research laboratories and typical university core facilities.  The PCE will use a diversity of commercial and custom sample handling approaches, mass spectrometers, and software to apply high performance and cutting-edge proteomics to a variety of cell lines, tissues, and mammalian tissues/fluids.  Northwestern University, the Robert H. Lurie Comprehensive Cancer Center and the Chicago Biomedical Consortium support the PCE.