Dr. Hossein Ardehali
Professor of Medicine & Pharmacology
RSVP / Register Here
- Date: Wed., February 27th
- Start Time: 11:00am
- Location: Silverman Hall, 3rd Floor Lobby (East Side)
- Food: Pizza (with RSVP)
Come grab a slice of Pizza and listen to Dr. Ardehali give a chalk talk about his research.
A chalk talk is a short 15-20 minute presentation given in front of a chalk board or in our case a dry erase board. The purpose is to present key ideas and concepts to better understand the vision of the research.
Dr. Ardehali will be presenting about his research - "The Role of Iron in Cardiovascular Physiology and Disease"
Role of iron in cardiovascular physiology and disease
Cellular and mitochondrial iron levels are tightly regulate, since excess iron can lead to oxidative stress, while low levels may lead to cellular dysfunction. We have identified a novel mitochondrial protein, ATP-Binding Cassette-B8 (ABCB8) that plays a role in mitochondrial iron homeostasis and mitochondrial iron export. Furthermore, a reduction in mitochondria iron is associated with improved cardiac function after treatment with doxorubicin, and in response to pressure overload and ischemia-reperfusion. We have developed novel iron chelators that can reduce mitochondrial iron, and we are planning to study these chelators in patients with ischemic heart disease and heart failure. Additionally, we showed that a pathway involving mTOR and tristetraprolin (TTP) plays a role in cellular iron regulation, and mediates “iron conservation”, as opposed to the “iron acquisition” pathway that is activated by iron-regulatory proteins (IRP). These processes and pathways, along with the effects of iron chelation and TTP activation on key mitochondrial electron transport chain (ETC) proteins, will be discussed. Finally, the effects of TTP on cellular metabolism will be highlighted.