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CLP Institute serves as host to two University Research Centers where researchers from different disciplines coalesce into teams dedicated to better understanding the molecular underpinnings of life and applying that knowledge to the development of new and better ways to detect, treat and diagnose disease. Each center makes available to the broader research community core facilities that serve researchers from three colleges and members of over twenty academic departments as well as scores of users from industry and other academic research institutions.

 

 

 

 

 Chicago Region Physical Sciences-Oncology Center

Researchers in the Chicago Region Physical Sciences-Oncology Center, led by CLP Director Thomas O’Halloran, are developing a powerful new interdisciplinary approach to cancer that couples the strengths of chemistry, engineering, and physics with molecular biology and medicine to determine the fundamental physical and chemical changes underlying cancer cell behavior. This new knowledge has become the foundation for a radically new approach to cancer treatment and early diagnosis.

 

 

 

 

Northwestern Proteomics

Northwestern Proteomics, led by Neil Kelleher, Walter and Mary E. Glass Professor of Molecular Biosciences, is a juggernaut for team science with collaborations extending to more than 100 investigators across both campuses. It is the only research center in the world that is devoted primarily to top-down proteomics.  This powerful, but challenging technique allows researchers to investigate intact proteoforms without prior digestion into peptides. This shift in approach propels a variety of national interests in technology development, systems biology, and clinical/translational proteomics.

Committed to disseminating these new proteomics methods and hands-on training for diverse laboratories and scientists, the center built and manages the Proteomics Core Facility that leads the region in providing top-down proteomics services to academic groups and corporations worldwide.  Northwestern Proteomics has generated more than $15 million in funding, spun out three companies and generated over 150 papers.