News Archive

Chromatin organizes itself into 3D ‘forests’ in single cells

Chromatin organizes itself into 3D ‘forests’ in single cells

A single cell contains the genetic instructions for an entire organism. This genomic information is managed and processed by the complex machinery of chromatin -- a mix of DNA and protein within chromosomes whose function and role in disease are of increasing interest...

Disorderly DNA Helps Cancer Cells Evade Treatment

Disorderly DNA Helps Cancer Cells Evade Treatment

Each cell in the human body holds a full two meters of DNA. In order for that DNA to fit into the cell nucleus — a cozy space just one hundredth of a millimeter of space — it needs to be packed extremely tight. A new Northwestern University study has discovered that...

Budding Scientist Flourishes at Northwestern

Budding Scientist Flourishes at Northwestern

Growing up in Michigan, Isabella (Bella) Borgula, a senior at Northwestern, developed a passion for chemistry earlier than most kids. “One thing that I distinctly remember is that my dad would buy me GIANT Microbes®, these little stuffed animals of viruses and...

Two Generations Find Their Way at Northwestern

Two Generations Find Their Way at Northwestern

Like many first-year students, Myung Shin ’87 was undecided about his major when he arrived at Northwestern. He was initially drawn to political science, but his parents had other plans. “They wanted me to go to medical school, but I didn’t know if that was right for...

2019 Chemistry of Life Processes Institute Discoveries and Impact

2019 Chemistry of Life Processes Institute Discoveries and Impact

This year, the Chemistry of Life Processes Institute celebrated a decade of transformative science. Since its debut in Silverman Hall in 2009, the Institute’s team science approach to integrating engineering, physics, chemistry, biology and medicine has led to...

Innovative Plastic Upcycling Project Receives 2020 CLP Cornew Award

Innovative Plastic Upcycling Project Receives 2020 CLP Cornew Award

The rampant proliferation of plastic in the environment, one of the world’s most widely used materials, is a massive and growing concern.  Over the past 50 years, the world has produced 8 billion tons of plastic. Less than half is reused, or recycled into new items....

CLP Faculty Get Kellogg Crash Course on Entrepreneurship

CLP Faculty Get Kellogg Crash Course on Entrepreneurship

When it comes to running a business, even the most seasoned innovators, like Chemistry of Life Processes Institute member Richard Silverman (chemistry) who developed pregabalin, the chemical that became Lyrica®, the most financially successful drug ever to have come...

Northwestern faculty elected to National Academy of Medicine

Northwestern faculty elected to National Academy of Medicine

Four Northwestern University professors have been honored with election to the National Academy of Medicine (NAM). Joining more than 2,200 active NAM members are Dr. David Cella, Dr. Susan Quaggin, John A. Rogers and Catherine Woolley. Rogers, who is already a member...

The Best Laid Plans of Mice and Medicine

The Best Laid Plans of Mice and Medicine

“My plan was to become a pharmacist,” says Irawati (Angki) Kandela, PhD, Assistant Director of the Developmental Therapeutics Core (DTC), a CLP-affiliated core facility, and Research Assistant Professor in the Pharmacology Department at Northwestern.  Growing up in...

Catching evolution in the act

Catching evolution in the act

Charles Darwin was right. In his 1859 book, “On the Origin of Species,” the famed scientist hypothesized that artificial selection (or domestication) and natural selection work in the same ways. Now an international team, led by Northwestern University, has produced...

Viewing Party to Celebrate National Chemistry Week

Viewing Party to Celebrate National Chemistry Week

In celebration of National Chemistry Week, Chemistry of Life Processes Institute (CLP) and Northwestern's Undergraduate Chemistry Council will host a free viewing party of American Chemical Society’s ‘Program in-a-Box Marvelous Metals’ on Tuesday, October...

Dissolvable Optical Sensor Moves Medicine Forward

Dissolvable Optical Sensor Moves Medicine Forward

Treating severe brain injury often requires immediate surgery, including implantation of an electronic sensor that monitors tissues and fluids and digitally provides real-time information about intracranial pressure, temperature and wound healing.  These devices,...

Building Better Biologics: A Q&A with Danielle Tullman-Ercek

Building Better Biologics: A Q&A with Danielle Tullman-Ercek

Building Better Biologics: A Q&A with Danielle Tullman-Ercek Like a master Lego® builder who constructs elaborate figures using tiny interlocking blocks, Chemistry of Life Processes Institute member Danielle Tullman-Ercek manipulates parts of bacteria and viruses...

Former CLP Trainee Brings Collaborative Mindset to AbbVie

Former CLP Trainee Brings Collaborative Mindset to AbbVie

Before becoming a trainee in the Chemistry of Life Processes NIH Graduate Training Program at Northwestern, Ryan McClure was already performing research at the interface of chemistry and biology. A joint student between the labs of Regan Thomson...

ALS drug grant to spur drug discovery at Northwestern

ALS drug grant to spur drug discovery at Northwestern

Two Northwestern University scientists have received a $3.1 million grant from the National Institute on Aging to collaborate and investigate drug therapies for amyotrophic lateral sclerosis (ALS). The grant was awarded to P. Hande Ozdinler, associate professor of...

CLP Research Tools, Expertise Continue To Grow

CLP Research Tools, Expertise Continue To Grow

Watching neurons die provides Richard Morimoto with clues on how he might better keep them alive. The molecular biologist specifically studies neurons exposed to cell stress as well as those expressing proteins linked to neurodegenerative diseases.Now, a new...

Found In Translation

Found In Translation

The deaths were palpable. Just six years after the start of a medical career he envisioned would be filled with helping patients heal, Richard D’Aquila, instead, found himself at the forefront of the AIDS epidemic. What he did next continues to alter the lives of...

‘Trojan horse’ anticancer drug disguises itself as fat

‘Trojan horse’ anticancer drug disguises itself as fat

For years, drug developers have tried, but failed, to build the perfect biological Trojan horse. Now, a new approach that disguises chemotherapeutic drugs as fat stands to outsmart, penetrate and destroy tumors. For the first time, a team of Northwestern researchers,...

CLP Collaborators Publish New Insight into Liver Cancer

CLP Collaborators Publish New Insight into Liver Cancer

Congratulations to NU scientists Richard B. Silverman and Neil L. Kelleher on their recent publication in the Journal of the American Chemical Society, titled “Mechanism of Inactivation of Ornithine Aminotransferase by (1 S,3...

Electron-behaving nanoparticles rock current understanding of matter

Electron-behaving nanoparticles rock current understanding of matter

It’s not an electron. But it sure does act like one. Northwestern University researchers have made a strange and startling discovery that nanoparticles engineered with DNA in colloidal crystals — when extremely small — behave just like electrons. Not only has this...

CLP Board sponsors undergraduate research

CLP Board sponsors undergraduate research

Training and inspiring the next generation of interdisciplinary scientists is central to the mission of the Chemistry of Life Processes Institute at Northwestern. This year, four aspiring scientists will join a growing list of students who have received funding...

Diverse, engaging job opportunities await CLP trainees

Diverse, engaging job opportunities await CLP trainees

With more than 30 years in the pharmaceutical industry, preceded by a decade as an independent researcher in academia, Chemistry of Life Processes Institute’s Entrepreneur-in-Residence William Sargent shared his perspective and advice about potential science career...

2019 CLP Cornew Awards kick-start three blue-sky team science projects

2019 CLP Cornew Awards kick-start three blue-sky team science projects

This year, three teams of Chemistry of Life Processes Institute investigators received $90,000, collectively, in CLP-Cornew Innovation Awards to pursue potentially transformative proof-of-concept studies to better detect, diagnose and treat disease.  The awardees...

CLP Trainee Jennifer Ferrer Aims High and Finds Her Balance

CLP Trainee Jennifer Ferrer Aims High and Finds Her Balance

Northwestern University graduate student and Chemistry of Life Processes Institute trainee Jennifer Rachel Ferrer will finish her PhD tomorrow as a joint student of Drs. Chad Mirkin (chemistry), and Jason Wertheim (surgery). She will present her research on how...

Guillermo Ameer receives University’s annual Walder Award

Guillermo Ameer receives University’s annual Walder Award

Guillermo A. Ameer, professor of biomedical engineering and surgery, has been named the 18th recipient of the Martin E. and Gertrude G. Walder Award for Research Excellence. A pioneer in the emerging field of regenerative engineering, Ameer is known for his creative...

Three scientists recognized as exceptional young researchers

Three scientists recognized as exceptional young researchers

Northwestern University faculty members William Dichtel, Michael Jewett and Emily Weiss have been named finalists for the 2019 Blavatnik National Awards for Young Scientists. They are among 31 scientists and engineers being recognized nationally this year. The...

Teaching CRISPR and antibiotic resistance to high school students

Teaching CRISPR and antibiotic resistance to high school students

How can high school students learn about a technology as complex and abstract as CRISPR? It’s simple: just add water. A Northwestern University-led team has developed BioBits, a suite of hands-on educational kits that enable students to perform a range of biological...

Biology Unlocked: Emerging Applications of Cell-Free Systems

Biology Unlocked: Emerging Applications of Cell-Free Systems

Today, biology is easier than ever to observe but still incredibly difficult to understand. Powerful advancements in DNA sequencing and synthesis have inched scientists ever forward in their quest to “master” biology. But countless challenges still remain. When...

Preclinical Imaging Consortium 2019

Preclinical Imaging Consortium 2019

CLP's Center for Advanced Molecular Imaging to Host the 5th Annual Preclinical Imaging Consortium April 28 - 30, 2019Northwestern UniversityNorris University Center, 2nd Floor1999 Campus Dr, Evanston, IL 60208 This week, the Chemistry of Life Processes...

Erik Andersen receives award to study the evolution of behavior

Erik Andersen receives award to study the evolution of behavior

Erik C. Andersen, a molecular geneticist at Northwestern University, has received a Human Frontier Science Program grant to study the evolution of behavior. Andersen will lead an international team to study the repeatability of the genetic mechanisms underlying...

Revealing the Rules Behind Virus Scaffold Construction

Revealing the Rules Behind Virus Scaffold Construction

A team of researchers including Northwestern Engineering faculty has expanded the understanding of how virus shells self-assemble, an important step toward developing techniques that use viruses as vehicles to deliver targeted drugs and therapeutics throughout the...

Promising young faculty receive prestigious career award

Promising young faculty receive prestigious career award

Three Northwestern University assistant professors — Nicholas Diakopoulos, Yevgenia Kozorovitskiy and Sepehr Vakil — have received the prestigious Faculty Early Career Development (CAREER) Award from the National Science Foundation (NSF), the foundation’s most...

A new approach to a deadly disease

A new approach to a deadly disease

A New Approach to a Deadly Disease A career spent bucking convention leads Bill Klein to new Alzheimer's diagnostics and therapeutics “When I was in graduate school, three papers per month were published on Alzheimer’s disease. Now, there are thousands every month.”...

New technology gives unprecedented look inside capillaries

New technology gives unprecedented look inside capillaries

More than 40 billion capillaries — tiny, hair-like blood vessels — are tasked with carrying oxygen and nutrients to the far reaches of the human body. But despite their sheer number and monumental importance to basic functions and metabolism, not much is known about...

In the Immune System’s Trenches, a New Discovery

In the Immune System’s Trenches, a New Discovery

Few everyday scenarios illicit as much trepidation as a nearby sneeze during flu season. Suddenly surrounded by tens of thousands of potentially virus-filled particles, a person’s evolving cellular reaction actually matters far more than the ability to shield one’s...

Full-Body Scan Could Improve Chemotherapy Effectiveness

Full-Body Scan Could Improve Chemotherapy Effectiveness

A new full-body scan could help clinicians to better assess toxicity during cancer treatment, according to a Northwestern Medicine study published in Clinical Cancer Research. The scan, which detects the presence of molecules exposed during tissue damage, could give a...

Young black gay men have vastly higher HIV rates yet fewer partners

Young black gay men have vastly higher HIV rates yet fewer partners

Young black men who have sex with men (MSM) are 16 times more likely to have an HIV infection than their white peers despite more frequent testing for HIV and being less likely to have unsafe sex, reports a new Northwestern Medicine study. The study was recently...

Altruism, curiosity drive CLP undergraduate awardee Viswajit Kandula

Altruism, curiosity drive CLP undergraduate awardee Viswajit Kandula

“As an undergrad, I finally thought I knew what I wanted to do, but I’ve been constantly swayed by new things that are creative and exciting,” says Viswajit Kandula, this year’s recipient of Chemistry of Life Processes Institute’s Chicago Area Undergraduate Research...

Faculty Perspectives: Cancer

Faculty Perspectives: Cancer

Almost everyone has been touched by cancer in some way — whether they are a patient, caregiver, family member or friend. And while new prevention protocols and treatment strategies are attacking cancer in amazing ways, Northwestern is pushing for even more innovation...

CLP Year in Review

CLP Year in Review

Highlights of 2018 2018 has been a year of transformative discovery and impact in Northwestern University’s Chemistry of Life Processes Institute. Some of the highlights of the past year include: The National Science Foundation awarded CLP faculty members Vadim...

Worldly worms offer clues about how evolution works

Worldly worms offer clues about how evolution works

The nematode roundworm, Caenorhabditis elegans, is tiny— about the size of a comma on a printed page— and yet it can reveal a lot about human genetics according to Chemistry of Life Processes Institute’s latest member Erik Andersen. Andersen, Assistant Professor of...

CLP member Guillermo Ameer, others named AAAS fellows

CLP member Guillermo Ameer, others named AAAS fellows

Three Northwestern University faculty members have been elected 2018 fellows of the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society. Guillermo Ameer, Jian Cao and Frederic Rasio have been recognized for their...

From undergraduate to biotech boss

From undergraduate to biotech boss

Chandler Robinson, CLP board member and Northwestern chemistry and math undergraduate, started a biotech company to develop a potentially life-saving drug, choline tetrathiomolybdate, for use in the treatment of Wilson’s Disease. That drug is nowin Phase III trials...

Where cancer lurks

Where cancer lurks

Vadim Backman, CLP resident member and Walter Dill Scott Professor of Biomedical Engineering, is featured on the Fall 2018  cover of Northwestern magazine. The story explains Backman’s path-breaking work in chromatin regulation to fight resistance in cancer and...

Arthur Prindle, CLP Member, receives 2018 Packard Fellowship

Arthur Prindle, CLP Member, receives 2018 Packard Fellowship

Arthur Prindle, PhD, assistant professor of Biochemistry and Molecular Genetics, has been named a 2018 Packard Fellow, one of 18 scientists across the globe recognized for their pursuit of scientific discovery. The fellowship, established by The David and Lucile...

Diabetes drug could prevent deaths from air pollution

Diabetes drug could prevent deaths from air pollution

An inexpensive drug for Type 2 diabetes also decreases the risk of heart attacks and strokes caused by air pollution, according to a new Northwestern Medicine study. The drug, metformin, is already used by more than 100 million people worldwide to treat diabetes. A...

Teresa K. Woodruff elected to National Academy of Medicine

Teresa K. Woodruff elected to National Academy of Medicine

Original story published in Northwestern News on 8/11/2018 by Kristin Samuelson.  Photo by Jim Prisching. CHICAGO (Northwestern Now) - Teresa K. Woodruff, vice chair for research in the department of obstetrics and gynecology at Northwestern University Feinberg School...

Chemists awarded $3.6 million to study quantum computing

Chemists awarded $3.6 million to study quantum computing

A group of Northwestern University chemists and engineers have been been awarded $3.6 million from the U.S. Department of Energy to support their work of creating better qubits, the smallest unit of a quantum computer. The grant is one of 85 research awards, totaling...

CLP board member Dr. Ulrich Thienel joins Finch Therapeutics

CLP board member Dr. Ulrich Thienel joins Finch Therapeutics

SOMERVILLE, Mass.--(BUSINESS WIRE)--Finch Therapeutics Group, Inc. (Finch), a clinical-stage microbiome therapeutics company, announced today that it has appointed Ulrich Thienel, Ph.D., M.D., as Chief Medical Officer and Gregory Perry as Chief Financial Officer. Dr....

Video: Cross-training tomorrow’s scientists

Video: Cross-training tomorrow’s scientists

VIDEO: Cross-training tomorrow’s scientists “CLP is the mothership for bringing the chemist and the biologist and engineers together.” – Rick Silverman, Patrick G. Ryan/Aon Professor, inventor of the blockbuster drug Lyrica® Solving the most pressing problems in human...

Campfire and chemistry inspire CLP donors

Campfire and chemistry inspire CLP donors

When Patrick Martin, Managing Director, Martin Investment Management, LLC, first heard about the idea to form a new institute at Northwestern University that would combine the strengths of different fields of study into one effort focused on finding new drugs and...

CLP welcomes two new board members

CLP welcomes two new board members

This year, two leaders in pharmaceuticals and bioscience, respectively, have joined the Chemistry of Life Processes Institute’s Executive Advisory Board. The newest members of the board are Sheila Westmoreland, DPM, MPH, PMP, senior director, Gene Therapy, Sarepta...

Sniffing out olfaction’s molecular underpinnings

Sniffing out olfaction’s molecular underpinnings

In the days leading up to President Barack Obama’s 2014 visit to Northwestern, neurobiologist Thomas Bozza began to see an influx of four-legged visitors to campus — dogs trained to recognize the chemical signature of explosives. “Humans are increasingly reliant on...

3-D Structure of COMPASS Protein Complex Revealed

3-D Structure of COMPASS Protein Complex Revealed

The three-dimensional atomic structure of the COMPASS protein complex has been detailed for the first time, according to a study published in the journal Cell. These findings will provide a platform for designing future cancer therapies, as the epigenetic regulator...

Chicago researchers develop new bandage that accelerates healing

Chicago researchers develop new bandage that accelerates healing

Original story published by Fox 32 on August 16 by Sylvia Perez Scientists at Northwestern University have developed a revolutionary new bandage. They say it can dramatically accelerate the healing time for wounds and they're hoping one day it'll be a must-have item...

Erik Andersen receives prestigious NSF honor for young faculty

Erik Andersen receives prestigious NSF honor for young faculty

Northwestern University’s Erik C. Andersen has received a Faculty Early Career Development Program (CAREER) award from the National Science Foundation (NSF), the foundation’s most prestigious honor for junior faculty members. Andersen will receive $500,000 over five...

Cheek swab may help diagnose precancers, early malignancies

Cheek swab may help diagnose precancers, early malignancies

Original article published on July 11, 2018 in Helio, HemOncToday by Rob Volansky Promising results for a simple cheek swab test to detect precancerous lesions in lung cancer may signify an era of affordable first-line diagnostic procedures, according to researchers...

Grad students, researchers talk science at CLP Core Crawl

Grad students, researchers talk science at CLP Core Crawl

More than 250 Northwestern graduate students, researchers and scientists gathered at Silverman Hall in July for the Chemistry of Life Processes Institute’s Core Crawl, an annual networking event and facilities expo. While enticing researchers with craft beer, pizza...

Bioengineers create pathway to personalized medicine

Bioengineers create pathway to personalized medicine

Cell-free glycoprotein synthesis provides cheaper, more rapid way to make medicines EVANSTON, Ill. — Engineering cellular biology -- minus the actual cell -- is a growing area of interest in biotechnology and synthetic biology. It’s known as cell-free protein...

New Center for Advanced Regenerative Engineering Launches

New Center for Advanced Regenerative Engineering Launches

Northwestern’s newest center has officially launched with a bold mission and interdisciplinary mindset. The Center for Advanced Regenerative Engineering (CARE) aims to create an ecosystem that enables researchers and clinicians to regenerate tissues and organs for...

C. elegans: An Elegant Model System for Determining Drug Responses

C. elegans: An Elegant Model System for Determining Drug Responses

Parasitic nematodes, known commonly as roundworms, infect one-third of the world’s human population and are a threat to livestock and pets.  There are only three general classes of anti-nematode (anthelmintic) drugs available to treat these parasites, and resistance...