amyr@northwestern.edu
(847) 467-5301

Methods pinpoint copper binding sites in enzyme from methane-munching bacteria

Methane-consuming bacteria could be the future of fuel

Bacteria eats greenhouse gas with a side of protein

CLP Member Amy Rosenzweig elected to National Academy of Sciences

Amy Rosenzweig, PhD

Weinberg Family Distinguished Professor of Life Sciences and Professor of Molecular Biosciences and of Chemistry, Weinberg College of Arts and Sciences

Member, Chemistry of Life Processes Institute

Rosenzweig is a leader in the fields of bioinorganic chemistry and structural biology. Her laboratory focuses on metalloproteins, which comprise up to 50 percent of all proteins. Rosenzweig’s work has provided seminal insights into how metalloenzymes catalyze complex and difficult chemical transformations and how cells acquire and distribute essential yet toxic metal ions.

Rosenzweig and her research group use X-ray crystallographic, spectroscopic, biochemical and genomic approaches to attack problems at the forefront of bioinorganic chemistry. Current areas of interest include biological methane oxidation, metal uptake and transport, and oxygen activation by metalloenzymes.

Her numerous honors include being elected a fellow of the American Academy of Arts and Sciences (2014) and a fellow of the American Association for the Advancement of Science (2007). Rosenzweig was named a MacArthur Fellow in 2003.

Rosenzweig received the Royal Society of Chemistry Joseph Chatt Award (2014), the American Chemical Society Nobel Laureate Signature Award for Graduate Education (2006) and an honorary Doctor of Science degree from Amherst College (2005). She is currently on the editorial boards of the journals Science and Biochemistry.

Publications

Balasubramanian, R.; Smith, S. M.; Rawat, S.; Yatsunyk, L. A.; Stemmler, T. L.; Rosenzweig, A. C. Oxidation of methane by a biological dicopper centre. Nature 2010, 465, 115-119.

Boal, A. K.; Cotruvo, J. A., Jr.; Stubbe, J.; Rosenzweig, A. C. Structural basis for activation of class Ib ribonucleotide reductase. Science 2010, 329, 1526-1530.

Traverso, M. E.; Subramanian, P.; Davydov, R.; Hoffman, B. M.; Stemmler, T. L.; Rosenzweig, A. C. Identification of a hemerythrin-like domain in a P1B-type transport ATPase. Biochemistry 2010, 49, 7060-7068.

Balasubramanian, R.; Levinson, B. T.; Rosenzweig, A. C. Secretion of flavins by three species of methanotrophic bacteria. Appl. Environ. Microbiol.2010, 76.

Walker, C. B.; de la Torre, J. R.; Urakawa, H.; Klotz, M. G.; Lawton, T. J.; Pinel, N.; Arp, D. J.; Brochier-Armanet, C.; Chain, P. S. G.; Chan, P. P.; Golabgir, A.; Hemp, J.;Hügler, M.; Karr, E. A.; Könneke, M.; Shin, M.; Lawton, T. J.; Martens-Habbena, W.; Sayavedra-Soto, L. A.; Lang, D.; Sievert, S. M.; Rosenzweig, A. C.; Manning, G.; Stahl, D. A. The Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification andautotrophy in globally distributed marine crenarchaea. Proc. Natl. Acad. Sci. USA 2010, 107, 8818-8823.

Boal, A. K.; Rosenzweig, A. C. Crystal structures of cisplatin bound to a human copper chaperone. J. Am. Chem. Soc. 2009, 131, 14196-14197.

Boal, A. K.; Rosenzweig, A. C. Structural biology of copper trafficking. Chem. Rev. 2009, 109, 4760-4779.

Lawton, T. J.; Sayavedra-Soto, L. A.; Arp, D. J.; Rosenzweig, A. C. Crystal structure of atwo-domain multicopper oxidase: implications for the evolution of multicopper blue proteins. J. Biol. Chem. 2009, 284, 10174-10180.

Hakemian, A. S.; Kondapalli, K. C.; Telser, J.; Hoffman, B. M.; Stemmler, T. L.; Rosenzweig, A. C. The metal centers of particulate methane monooxygenase from Methylosinus trichosporium OB3b. Biochemistry2008, 47, 6793-6801.

Lieberman, R. L.; Rosenzweig, A. C. Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane, Nature2005, 434, 177-182.

Select Honors and Awards
  • Elected Fellow, American Academy of Arts and Sciences 2014
  • Elected Fellow, American Association for the Advancement of Science, 2007
  • American Chemical Society Nobel Laureate Signature Award for Graduate Education, 2006
  • Honorary Degree, Doctor of Science, Amherst College, 2005
  • MacArthur Fellow, 2003
  • Camille Dreyfus Teacher Scholar Award, 2001
  • David and Lucile Packard Fellow, 1999
  • Her numerous honors include being elected a fellow of the American Academy of Arts and Sciences (2014) and a fellow of the American Association for the Advancement of Science (2007). Rosenzweig was named a MacArthur Fellow in 2003.