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From cutting-edge nanoscale imaging platforms to sophisticated computational modeling of drug target interactions, Chemistry of Life Processes Institute’s affiliated centers and cores offer a deep bench of tools for discovery, analysis, and visualization.  These technologies make possible steady progress in the understanding of the molecular underpinnings of cancer, Alzheimer’s disease, HIV, and more. Our expertise in developing therapeutics, and understanding the study of proteomics, epigenetic strategies to control cancer, and the role of metals in human health, distinguishes CLP from other major biomedical institutes.

CLP provides researchers and clinicians from Northwestern, industry and other academic institutions a comprehensive tool-set for identifying, developing and testing new drugs and approaches to therapeutics intervention.

Our resources include:

  • Instruments and expertise needed to perform high throughput robotic testing for potential drug candidates
  • Computational approaches to improving drug design
  • Access to industry-quality expertise in synthesis of chemical compounds to improve the chemical features of potential drug candidate to increase potency and specificity
  • Capabilities for preclinical testing for toxicity and efficacy

Centers

Center for Developmental Therapeutics

Project management and consulting services for therapeutic translational projects. The Center works in collaboration with the Innovations and New Ventures Office to facilitate commercialization of therapeutic technologies.

Center for Molecular Innovation & Drug Discovery

Collaborative research platform and educational opportunities that integrate biologists and chemists to enhance interdisciplinary drug discovery research.

Chicago Region Physical Sciences-Oncology Center

Multi-investigator team science intiative organized around the conceptual framework that addresses the spatio-temporal organization of chromation and the information transfer in cancer.

Northwestern Proteomics

Develops and applies tools to analyze proteins using mass spectrometry. The Center focuses on the continuous innovation of technology to meet growing demands for analysis of proteins, specializing in intact protein analysis; while handling multiple projects large and small.

The Institute manages eight shared research facilities. These facilities represent a $25M investment in high‐end instrumentation and expertise and provide 50 new services that enable investigators to identify, design and refine potential new therapeutics and diagnostics and to visualize their activity in living cells and tissues. The cores’ PhD level personnel develop powerful new tools and methods to support new basic and translational research at Northwestern and across the Midwest.

Center for Advanced Molecular Imaging

Imaging resources span length scales of molecules to whole animals. Instruments include MRI, IVIS Spectrum, SPECT, and PET.

ChemCore

Medicinal and synthetic chemistry, molecular modeling and compound purification services.

Biological Imaging Facility

Photonic and electron instruments, allowing researchers to capture high-quality images and videos of their specimens.

Developmental Therapeutics Core

Operational laboratory that supports translational projects and exploratory drug development work.

High Throughput Analysis Laboratory

Instrumentation and expertise for the development and execution of high throughput biological analysis and screening.

Proteomics Core

Instrumentation and expertise to analyze proteins using mass spectrometry. Specializing in intact protein analysis.

Quantitative Bio-element Imaging Center

Quantitation and localization of bioelements using ICP mass spec, customized Hitachi HD2300 STEM for cryo-bio EM, and atomic absorption mass spectometry.

Recombinant Protein Production Core

Expression and purification of recombinant or synthetic biologics and cultivation of microbial, insect, and mammalian cells.